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KMID : 0363320050260010156
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Journal of Korean Oriental Internal Medicine
2005 Volume.26 No. 1 p.156 ~ p.168
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Effects of Pinelliae Rhizoma on immunocyte and cytokine production in asthma model mouse
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Song Jae-Jin
Park Yang-Chun
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Abstract
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Objective : The purpose of this research is to examine the effects of Pinelliae Rhizoma (PR) extract on immune cells and cytokines in ovalbumin (OVA)-induced asthmatic mice.
Methods : In vivo, C57BL/6 mice were sensitized and handicapped by OVA for 12 weeks. During this experiment, the one group was then treated with PR extract for the 8 weeks (3 times per week) and analyzed by ELISA and flow cytometer.
Results : In vivo, there were significant decreases in eosinophils, IL-4, IL-5, IL-13, IgE in BALF (bronchoalveolar lavage fluid) compared with that of control group. However, IFN-{gamma} in BALF of GS group increased significantly, compared with that of control group. Additionally, the population of CD3e-/CCR3+,;CD69+/CD3e+,;IgE+/B220+,;CD11b+/Gr-l+ cells in the PR group decreased, compared with that of control group.
Conclusion : The results of this study support a role for PR as an effective treatment for asthma in its experimental success in significantly decreasing inflammation and asthma reactions, and in increasing IFN-{gamma}, which helps prevent such reactions.
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KEYWORD
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Pinelliae Rhizoma, asthma, cytokine
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